The 3D structure of a protein is essential to understand of its biological function and the design of drug candidates. Homology modeling is the most accurate approach for protein 3D structure prediction with atomic-resolution.
Development of homology model includes several main steps such as:
- Template recognition and initial alignment
- Alignment correction
- Backbone generation
- Loop modeling
- Side-chain modeling
- Model optimization
- Model validation
Our team has significant experience of homology modeling various monomeric and oligomeric proteins with subsequent use the results for the drug design.
Otava Institute offers the service of prediction of tertiary-structure of protein using homology modeling methods.
Feel free to contact us.